Micro-electromechanical Film Bulk Acoustic Sensor For Plasma And Entire Blood Coagulation Monitoring
Monitoring blood coagulation is an important concern within the surgeries and BloodVitals experience the remedy of cardiovascular diseases. On this work, we reported a novel technique for BloodVitals experience the blood coagulation monitoring based mostly on a micro-electromechanical film bulk acoustic resonator. The resonator was excited by a lateral electric field and operated underneath the shear mode with a frequency of 1.9GHz. In accordance with the apparent step-ladder curves of the frequency response to the change of blood viscoelasticity, the coagulation time (prothrombin time) and the coagulation kinetics have been measured with the pattern consumption of solely 1μl. The procoagulant exercise of thromboplastin and the anticoagulant impact of heparin on the blood coagulation process have been illustrated exemplarily. 0.99969 and a consistency with the coefficient of variation lower than 5% compared with the commercial coagulometer. The proposed film bulk acoustic sensor, which has the benefits of small size, mild weight, low value, easy operation and little sample consumption, is a promising system for miniaturized, BloodVitals test online and automated analytical system for routine diagnostics of hemostatic standing and personal health monitoring.
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